scielobrjaos nanotechnology in ligature-inducedscielobrjaos结扎诱导的纳米技术.pdf

J Appl Oral in ligature-induced periodontitis: protective effect of a doxycycline gel with nanoparticulesMarco Antonio BOTELHO1, Jose Galberto MARTINS2, Ronaldo Sousa RUELA3, Dinalva Brito QUEIROZ4,Wagner Sousa RUELA31- Post Doctor in Orthodontics, Federal University of Ceará, Fortaleza, CE, - Doctor in Chemistry, Regional University of Cariri, Fortaleza, CE, - Doctor in Dentistry, Scholar of National Research and Development Pq, FUNORTE School of Dentistry, Montes Claros, MG, - Scholar of National Research and Development Pq, Fortaleza, CE, address: Prof. Dr. Marco A. Botelho - Instituto Federal de Educa??o Ciência e ologia do Ceará /Campus Canindé Departamento de Pesquisa & Inova??o ológica Laboratório de ologia - Br 020 - Km 303 - Jubaia - 62700-000 - Canindé, CE - Brasil - Phone : 55 (85) 3307-3600 / 8665-5000 - e-mail: ******@: January 09, 2009 - Modification: August 11, 2009 - Accepted: February 16, 2010Objectives: The aim of this study was to test the efficacy of a locally applied % nanostructured doxycycline (DOX) gel in preventing alveolar bone loss in experimental periodontal disease (EPD) in rats by using the tapping mode atomic force microscopy (AFM). Material and Methods: EPD was induced in 24 Wistar rats. Animals were treated with the doxycycline gel topically, i