＂Maximum Likelihood Haplotyping for General Pedigrees.＂.ppt

"eneralPedigrees."FishelsonM.,,iclinkage:basicdefinitionsSuperlink:putationorderSolvingproblemviaElim-MaxExperimentalresultsHumanGenomeMosthumancellscontain46chromosomes:2sexchromosomes(X,Y): XY–inmales. XX–,–––-onstitutionofanindividual,inheritedinstructionsitcarries,-anism(suchasmorphology,development,orbehavior)‏icmarker–aknownDNAsequence,variation,whichmayariseduetomutationoralterationinthegenomicloci,(SNP)orlongone(minisatellites)‏Locus–locationofmarkers-fixedpositiononachromosomeAllele–:A1,A2Locus2PossibleAlleles:B1,B2,B3Alleles-theABO(Bloodtypes)locusexampleMultiplealleles:A,B,,B/OBA/A,A/OAGenotypePhenotypeMendel’sfirstlawCharactersarecontrolledbypairsofgeneswhichseparateduringtheformationofthereproductivecells(meiosis)‏AaAaSexualReproductionzygotegametesspermeggMeiosisMendel’ssecondlawWhentwoormorepairsofgenessegregatesimultaneously,;BbABAbaBabPAB=PAPBPAb=PAPbPaB=PaPBPab=PaPb