细胞信号转导障碍与疾病.ppt

细胞信号转导障碍与疾病(Dysfunction of Cellular signal transduction in disease)
北京大学医学部病理生理室 吴立玲
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Clinical example
A 37-year-old woman worked as a nursing assistant in the hospital.
In recent years she was noticed that her low jaw protruded(突出) and her teeth separated.
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These changes were most apparent pared with her high school picture.
Her hat, glove, and shoe size also had increased.
Her fingers were so enlarged that it was hard for her to fasten the little snaps and tie the ties on the shirts.
Clinical example
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Clinical example
Physical examination revealed a large woman with coarse(粗糙) facial features, a prominent jaw, and large, broad hands and feet.
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Clinical example
Question
What had happened on the  patient?
What kind of examination  should she take for diagnosis?
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Cellular signal transduction
膜受体介导的跨膜信号转导
核受体介导的信号转导
细胞信号转导
信息分子通过作用于受体及其信号转导分子而影响细胞生物学功能的过程。
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Transmembrane signal transduction
跨膜信号转导
胞外信息分子与膜受体结合,将信息传递至胞浆或核内,调节靶细胞功能的过程。
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核受体介导的信号转导
信息分子与核受体结合启动靶基因转录的过程。
Nuclear receptor-mediated signal transduction
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核受体(Nuclear receptor)
位于胞浆或核内的受体,激活后作为转录因子,在核内调节靶基因的转录。
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(The primary pathways of cellular signal transduction)
第一节
细胞信号转导的主要通路
医学课件园