Principles of Clinical Pharmacology临床药理学原理.doc

PRINCIPLES OF CLINICAL PHARMACOLOGY
Steven P. Stratton, .
Research Associate Professor of Medicine
University of Arizona
Address: Arizona Cancer Center
1515 N Campbell Ave
PO Box 245024
Tucson, AZ 85724
(520) 626-9295
Running Title: Clinical Pharmacology
Learning Objectives
Define ics & Pharmacodynamics
Identify ic/pharmacodynamic approaches, terminology, and parameters
Recognize and develop endpoints for ic/pharmacodynamic modeling
Identify barriers to molecularly targeted drug development
Understand practical considerations in design of ic studies in clinical protocols
Introduction to ics and Pharmacodynamics
Antineoplastic chemotherapeutic agents have the lowest therapeutic indices monly used classes of drugs1. The distinction between drug and poison is very small. Thus, pharmacologically rational approaches are crucial to avoiding disastrous es.
A drug is any pure chemical substance that alters a normal physiologic process when administered to anism. To study how drugs work, pharmacologists have mystified the process by plex terms to describe relatively simple concepts. These terms include ics and pharmacodynamics. There are four possible es following drug administration. These es include:
Efficacy without toxicity
Efficacy with toxicity
Toxicity without efficacy
Neither toxicity nor efficacy
ic and pharmacodynamic modeling incorporated int