《自身免疫研究生》.ppt

该【《自身免疫研究生》 】是由【相惜】上传分享，文档一共【64】页，该文档可以免费在线阅读，需要了解更多关于【《自身免疫研究生》 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。考试时间:12月2日1:30-3:30地点:第28教室通知整理pptSelftoleranceandAutoimmunity整理pptPartIicmechanismsofselftoleranceandautoimmunity整理pptGOALOFTHEIMMUNESYSTEMSeparateselffromnon-selfStayinharmonywithselfantigensandtissuesofthehost整理pptV(D)binationassemblesuniqueBCRandTCRgenesfromthreeseparategenesegments,thevariable(V),diversity(D)andjoining(J)genes,duringB-andT-(suchasthespleen,lymphnodesandtonsils).整理pptBetween20and50%ofTCRsandBCRsgeneratedbyV(D)?8%:thefailuretomountanimmuneresponsetoselfantigens(endogenousantigens)-Note:failure=/=passivity;toleranceisactive整理pptImmunologicallyspecific(.,specificepitopes)Learnedoracquired(.,activeprocess)ImmatureordevelopinglymphocytesmoresusceptibletotoleranceinductionthanmaturelymphocytesInadequatestimulationofmaturecellscanleadtotolerancePrimarilyafunctionofTcells;howeverBcellscanbetolerizedTcelltolerance:longlived,requireslessAgstimulationBcelltolerance:shorterlived,requiresmoreantigenCHARACTERISTICSofTOLERANCE整理ppt整理pptans:ArrestofimmatureB-cellmaturation;Ifthestrengthofreceptorcrosslinkingandintracellularsignallingexceedsacertainthreshold,,suchasCD62ligand(CD62L),-cell-activatingfactor(BAFF),acirculatingcytokinerequiredtosustainperipheralB-cellsurvival,(bination-activatinggene1)andRAG2,whichencodethecoreenzymesforV(D)bination,